Researchers identify promising target for halting lung cancer
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| LDH-A is elevated in NSCLC, courtesy of Wikipedia |
SCIENCE DAILY – April 11, 2014 – Researchers have found that targeting an enzyme tumors use to accelerate cell division and growth not only halts tumor growth in mouse models of non-small-cell lung cancer, but actually caused the tumors to grow smaller. The enzyme LDH-A is elevated in cancer cells, and shifts the function of glucose processing from simple energy production to accelerated cell growth and replication. The team at the Cancer Center at Beth Israel Deaconess Medical Center showed that when LDH-A was blocked, not only did the tumors stop growing, they actually shrank in size. They reported their findings in the online April 10 in the journal Cell Metabolism.
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