Wednesday, June 18, 2014

Bacteria boosts survival in pancreatic cancer immunotherapy

Smitha Krishnamurthi, MD, Case Western Reserve
University, describes the CRS-270/GVAX trial
YouTube by Targeted Oncology
Cancer Digest — June 12, 2014 — Researchers at the Virginia G. Piper Cancer Center at Scottsdale Health care is one of 11 centers studying a new pancreatic cancer immunotherapy that uses modified bacteria to boost the immune response to advanced pancreatic cancer.

In a recently completed early phase trial of 93 patients with advanced pancreatic cancer, those who received the combination regimen of CRS-207, GVAX and cyclophosphamide survived an average of 6.1 months compared to 3.9 months for those who received only cyclophosphamide and GVAX. CRS-207 is a modified bacteria, called Listeria that has the effect of increasing the immune response to the cancer. The GVAX is vaccine that causes the tumor to grow nodules that make the cancer susceptible to the immune system’s cancer-killing cells. The immunotherapies were well-tolerated, with no serious treatment-related adverse side effects.

Virginia G. Piper Cancer Center Clinical Trials is among the first 11 centers in the United States participating in the study. The drug was developed by Aduro BioTech, Inc., a clinical-stage immunotherapy company located in Berkeley, Calif. A total of 240 patients are expected to be treated at more than 20 clinical trial sites in North America.

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