Saturday, February 17, 2018

Accuracy of tests for predicting breast cancer recurrence vary significantly

Image courtesy Queen Mary
University of London
CANCER DIGEST – Feb. 17, 2018 – Tests used to predict breast cancer recurrence vary significantly in accuracy according to the first side-by-side comparison of the four most common tests.

In a study published in the Feb. 15, 2018 journal JAMA Oncology researchers led by Ivana Sestak, PhD of the Centre for Cancer Prevention at Queen Mary University of London, compared the predictive performance of the four most widely used biomarker analysis tests: Oncotype DX, PAM50, Breast Cancer Index (BCI) and the EndoPredict (EPclin), which all work by looking at the levels of multiple genes related to breast cancer.

“Being able to accurately predict the risk of breast cancer recurrence is even more important now that we are in an era where women are prescribed preventive endocrine (hormone) therapy for many years," said Sestak in a press release. "If we were better able to accurately assess a woman’s long-term risk, then some women may be able to end their endocrine therapy after five years. But for those deemed high risk of a late recurrence, continuing their endocrine therapy would be a valuable option.”

All of the tests have been endorsed by the major practice guidelines and European and US regulatory agencies but, until now, had never been compared for prognostic accuracy. 

The researchers compared the four tests’ ability to predict recurrence in a group of 774 postmenopausal women with the most common form of breast cancer, i.e. tumors that tested positive for estrogen receptors (ER+) and negative for the HER2 gene. They compiled the test results from the patients’ original tumor biopsies and then looked at recurrence among the women.

The team found that all four tests do provide substantial value for predicting recurrence of breast cancer up to 10 years after start of treatment in women whose tumors were negative for estrogen receptors (ER) and the HER2 gene.

For the critical time period of 5 to 10 years after treatment start, however, the results varied, since over 50 percent of women with estrogen receptor positive breast cancer recur within that time period. For those women the BCI, ROR and EPclin tests were more accurate in sorting which women had low-risk tumors from those with high-risk tumors.

For women whose tumors were ER+
 and HER2+ only the ROR and EPclin tests, which include clinical information, such as tumor size, number of positive lymph nodes, etc. more accurately predicted recurrence. 

1 comment:

    Clara I’m a citizen of USA, My younger sister was sicking of
    breast cancer and her name is David Sandra I and my family have taking her
    to all kind of hospital in USA still yet no good result. I decided to go to
    the internet and search for cancer cure so that was how I find a lady
    called peter Lizzy she was testifies to the world about the goodness of a
    herbal man who has the root and half to cure all kind of disease and the
    herbal man email was there. So I decided to contact the herbal man for my
    younger sister help to cure her breast cancer. I contacted him and told him
    my problem he told me that I should not worry that my sister cancer will be
    cure, he told me that there is a medicine that he is going to give me that
    I will cook it and give it to my sister to drink for one week, so I ask how
    can I receive the cure that I am in USA, he told me

    That I will pay for the delivery service. The courier service can
    transport it to me so he told me the amount I will pay, so my dad paid for
    the delivery fee. two days later I receive the cure from the courier
    service so I used it as the herbal man instructed me to, before the week
    complete my sister cancer was healed and it was like a dream to me not
    knowing that it was physical I and my family were very happy about the
    miracle of Doctor so my dad wanted to pay him 5 million us dollars the
    herbal man did not accept the offer from my dad, but I don't know why he
    didn't accept the offer, he only say that I should tell the world about him
    and his miracle he perform so am now here to tell the world about him if
    you or your relative is having any kind of disease that you can't get from
    the hospital please contact you can also visit his website / or whatsapp him
    +2348110114739 you can follow him up on instagram herbalist sakura for the cure, he will help you out with the
    problem. And if you need more information about the doctor you can mail me OR whatsapp +12092621508