Saturday, October 14, 2017

Newly approved breast cancer drug may work for lung cancer


This image shows autophagic vesicles containing
mutant K-Ras formed in the membrane of human
pancreatic cancer cells after exposure to neratinib –
Image courtesy VCU.
CANCER DIGEST – Oct. 14, 2017 – Researchers have found that a recently approved breast cancer drug may block the action of a trio of cancer-causing genes, known as Ras, which are implicated in a number of other cancers, including non-small cell lung cancer.

The drug neratinib was designed to inhibit enzymes produced by two other genes, EGFR and HER2, which make enzymes that regulate cancer cell growth and resistance to chemotherapy.

Wednesday, October 4, 2017

Do expensive new cancer drugs really improve survival?


CANCER DIGEST – Oct. 4, 2017 – That’s the question a group of British researchers at King’s College in London asked for a study published today in the British Medical Journal (BMJ).

The study looked at the clinical data for cancer drugs approved by the European Medicines Agency, the European version of the US FDA, between 2009 and 2013. They found that of the 68 drugs approved during that period, 39 (57%) were approved on the basis of surrogate endpoints. This is essentially an endpoint that is substituted for an actual outcome. This is done to speed approvals of certain drugs.

Saturday, September 23, 2017

Nearly all Americans take at least one step to prevent cancer

CANCER DIGEST – Sept. 23, 2017 – Cancer prevention, an idea the American Cancer Society and the National Cancer Institute have been preaching for decades seems to have taken hold, according to a new survey by the Mayo Clinic.

The annual Mayo Clinic National Health Checkup survey released last week shows that 95 percent of respondents take at least one preventive measure to avoid cancer. Started last year, health checkup survey aims to provide a quick pulse on consumer health opinions and behaviors at multiple times throughout the year.

Saturday, September 16, 2017

Diet and lifestyle play a major role in colorectal cancer

CANCER DIGEST – Sept. 16, 2017 – Nearly half of all colorectal cancer can be prevented with exercise and dietary changes, research shows, and a new study confirms that exercise and whole grains lower the risk while alcohol, red meat, processed meats and obesity increase the risk.

The new study by the American Institute for Cancer Research (AICR) and the World Cancer Research Fund confirms earlier research. Led by Dr. Edward Giovannucci, professor of nutrition and epidemiology at the Harvard TH Chan School of Public Health the study was published in the AICR’s own newsletter. It analyzed data from 99 previous studies that involved a total of 29 million people, including more than 250,000 diagnosed with colorectal cancer.

Saturday, September 9, 2017

Zika virus kills brain cancer, may be potential treatment


Brain cancer stem cells (left) are killed by Zika
virus infection (right). – photo courtesy
Washington University 
CANCER DIGEST – Sept. 9, 2017 – The Zika virus kills brain cancer stem cells and may be an effective treatment for glioblastoma, a deadly form of brain cancer, say researchers from Washington University and the University of San Diego School of Medicine.

The findings, published Sept. 5 in The Journal of Experimental Medicine showed laboratory results of glioblastoma tumors removed from patients that the researchers infected with two strains of Zika virus.