Tuesday, May 27, 2014

Phase 2 results in CPXcitement for AML

YouTube courtesy Leukemia and
Lymphoma Society of Canada
CANCER DIGEST – May 27, 2014 – Results from a small phase 2 clinical trial of a new chemotherapy for acute myeloid leukemia (AML) were favorable enough that researchers at the Moffitt Cancer Center in Tampa, FL, are now recruiting for a larger comparison clinical trial to determine effectiveness. AML is an aggressive blood cancer with very low rates of treatment success. The new drug called CPX-351 “encapsulates” two chemotherapy drugs, cytarabine and daunorubici, in a lipid shell that maintains the effective ratio of the two drugs until delivery to the tumor. In the early trial of 126 newly diagnosed AML patients those who received CPX-351 and whose AML arose out of a previously diagnosed hematologic disorder, such as myelodysplastic syndrome, had higher rates of remission and survived longer, although the objective of the trial was to determine the safest, most effective dose, not survival. The phase 3 CPX-351 clinical trial is currently open and recruiting patients and is designed to measure survival. Those interested in learning more about study should contact Clinical Research Coordinator Nancy Hillgruber at Nancy.Hillgruber@Moffitt.org. The results from the phase 2 study appeared in the May 22, 2014 journal Blood. An accompanying editorial explains why researchers are optimistic about CPX-351.

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