Colorectal Cancer

Saturday, May 27, 2017

Where your fat is carried can predict cancer risk

CANCER DIGEST – May 27, 2017 – Scientists have found that carrying fat around your middle could be as good an indicator of cancer risk as body mass index (BMI), according to research published in the British Journal of Cancer.

This is the first study comparing adult body measurements in such a standardized way for obesity-related cancers. The study combined data from more than 43,000 participants who had been followed for an average of 12 years and more than 1,600 people were diagnosed with an obesity-related cancer.

Wednesday, May 17, 2017

Nanovaccine shows promise for variety of cancers


Laser light is scattered by nanoparticles
in a solution of the UTSW-developed
nanovaccine. – 
Photo courtesy UTSW
CANCER DIGEST – May 17, 2017 – In another approach using nanotechnology to boost the body’s immune system to attack cancer, researchers at the University of Texas Southwestern’s Simmons Cancer Center, have shown in a proof-of-concept study that a nanovaccine extended survival in mouse models of a variety of cancers.

The study published online in the journal Nature Nanotechnology showed effective anti-tumor action in tumor models of melanoma, colorectal cancer, and HPV-related cancers of the cervix, head, neck and anogenital cancers.

Saturday, April 29, 2017

Follow-up colonoscopy could substantially cut cancer risk

CANCER DIGEST – April 29, 2017 – As much as you might hate it, undergoing that follow-up colonoscopy might cut your risk of colorectal cancer by half, a new analysis of colonoscopy data shows.

British researchers looked at data for more than 250,000 patients and identified approximately 12,000 people who were diagnosed with intermediate-risk adenomas across 17 UK hospitals. These patients were monitored over an eight year period, and the incidence of bowel cancer was compared in those who had a follow-up colonoscopy with those who had not.

Saturday, April 22, 2017


Researcher closing in on less invasive colon cancer test

Manasi Shah, Ph.D.
CANCER DIGEST – April 22, 2017 – If you’ve ever undergone a colonoscopy, you know why researchers are looking for a less invasive way to screen for colorectal cancer. 

Colonoscopy is currently the gold standard for detecting cancer, but it is a 2-day procedure that is expensive and dreaded by many. Patients need to drink a disagreeable laxative preparation to clean out the colon one day before the doctor threads a flexible colonscope through the intestines to look for and removing suspicious polyps

Sunday, April 9, 2017

Long-term aspirin use continue to show benefits


Yin Cao, MPH, ScD
CANCER DIGEST – April 9, 2017 – The evidence supporting the benefits of low-dose daily aspirin to prevent cancer continues to grow. In a study presented at the American Association for Cancer Research meeting taking place in Washington, D.C. this week, a large long-term study of nurses shows that the overall risk of dying was 7 percent lower for women and 11 percent lower for men who had regularly taken aspirin.

The Nurses’ Health System Study began in 1976 and has followed more than 280,000 nurses since that time using repeated questionnaire and follow-up assessments since the study began. 

Saturday, January 21, 2017

ACA increased colorectal cancer screening

The study’s coauthors are Brett Lissenden, a fifth-year
student in UVA’s economics Ph.D. program, and Aaron
Yao, an assistant professor in the Department of Public
Health Sciences. (Photo by Dan Addison, University
Communications)
CANCER DIGEST – Jan. 21, 2017 – The Affordable Care Act increased cancer screenings, and especially increased colorectal cancer screenings between 2011 and 2013, say researchers at the University of Virginia.

One of the main goals of the law that came to be known as Obamacare was to reduce healthcare costs in part by increasing coverage for prevention care on the theory that treating certain diseases such as cancer is less expensive when caught early when the disease is more treatable.

Saturday, August 6, 2016

Patch eliminates colorectal cancer


Researchers at MIT are developing 
an adhesive patch that can stick to 
a tumor site, either before or after 
surgery. – Image courtesy IMES
CANCER DIGEST – Aug. 6, 2016 – One day your doctor may use a patch, much like nicotine patches used to help people stop smoking, to eradicate colon cancer and keep it from coming back, according to a report in the journal Nature Materials.

In an experiment done in mice, researchers at MIT’s Institute for Medical Engineering and Science, have shown that the patch, designed to deliver a triple combination of therapies, was effective whether the tumor was completely removed or not. By contrast, 40 percent of the mice with no patch applied after tumor removal, saw tumor recurrence.

Sunday, July 31, 2016


Blocking glutamine may starve colorectal cancer cells

A molecular model of L-glutamine. Image courtesy Jynto
via Wikimedia Commons
CANCER DIGEST – July 31, 2016 – A new clinical trial set to get under way later this summer will try to determine if denying certain types of colorectal cancer cells a specific nutrient will starve them to death.

The Case Western Reserve University trial is based on laboratory and mouse studies showing that colorectal cancer cells with a genetic mutation called PIK3CA died when deprived of the nutrient glutamine, which is an amino acid used by cells to make proteins. This mutation is located in a gene critical for cell division and movement, and is found in approximately one third of all colorectal cancers.Glutamine is the most abundant free amino acid in human blood and is mostly made in muscle tissue.

  0 commentsMonday, August 17, 2015

Aspirin may reduce bowel cancer risk for obese people


Two examples of colorectal tumors
– via Wikipedia
CANCER DIGEST – Aug. 17, 2015 – A regular dose of aspirin reduces the long-term risk of cancer in those who are overweight with a family history of the disease, an international study has found.

The large clinical trial is part of an ongoing CAPP 2 study that is being conducted by scientists and clinicians from over 43 centers in 16 countries, and has been following nearly 1,000 patients with Lynch Syndromean inherited genetic disorder which affects genes responsible for detecting and repairing DNA damage. 

Wednesday, May 13, 2015

Drug combination extends survival in advanced colorectal cancer


CANCER DIGEST – May 13, 2015 – A drug developed 50 years ago and abandoned because it was considered to be too toxic, extended survival for colorectal cancer patients whose standard treatments were no longer working. 

Scientists at Dana-Farber Cancer Institute in Boston led the clinical trial involving 800 patients worldwide. Results showed the drug in combination with another agent lengthened the lives of patients with metastatic colorectal cancer by an average of almost two months. All participants had metastatic colorectal cancer that was progressing despite previous treatment.

Tuesday, May 5, 2015

Diet swap has dramatic effects on colon cancer risk


CANCER DIGEST – May 5, 2015 – The relationship between dietary fiber and colorectal cancer has been confirmed in many research studies, however a new study suggests the role of fiber in preventing cancer may be even greater than had been thought.

Thursday, April 23, 2015

Toxic mushroom may offer new cancer therapy


CANCER DIGEST – April 22, 2015 – For some time cancer scientists have considered the toxin found in “death cap” mushrooms, called alpha-amanatin, as a possible colorectal cancer treatment. While it has been shown to kill cancer cells, its drawback has been the unacceptable damage it causes to the liver.

In a study published April 22, 2015 in the journal Nature, researchers led by Xiongbin Lu, PhD at The University of Texas MD Anderson Cancer Center may have found a way to limit the liver toxicity of alpha-amanatin.

Thursday, March 26, 2015

Men’s midlife fitness linked to lower risk of cancer and death


CANCER DIGEST – Mar. 26, 2015 – Men who exercise and stay fit, especially in midlife, could be lowering their risk of lung cancer and colorectal cancer, but not prostate cancer, researchers say. Before you say two out of three isn’t bad, while fitness didn’t protect against getting prostate cancer fit men appear to be less likely to die of the disease.

Led by Dr. Susan Lakoski of the University of Vermont, Burlington, the researchers looked at Medicare data from 1999 to 2009 for a link between midlife cardiorespiratory fitness and cancer and survival following a cancer diagnosis at the Medicare age of 65 or older. 

Friday, January 23, 2015

Colorectal Cancer Increasing in Young Adults


Photo courtesy: Journal of
Young Adult Oncology
CANCER DIGEST – Jan. 23, 2015 – The incidence of colorectal cancer (CRC) among young adults ages 20-39 years has increased during the past 20-30 years, despite declining rates of CRC for the U.S. population overall, a new analysis shows.

Researchers at the University of California, Irvine, led by Kathryn Singh, MPH, MS, analyzed more than 231,500 CRC cases over a 22-year period, including 5,617 cases affecting young adults. The study appears online in the Journal of Adolescent and Young Adult Oncology.

Wednesday, January 14, 2015


Chemo nearly doubles survival rate for advanced colorectal cancer

CANCER DIGEST – Jan. 14, 2015 – The survival rate of people with advanced colorectal cancer has nearly doubled since newer chemotherapies were introduced in 2001, a new study shows.

Researchers led by Chung-Yuan Hu, M.P.H., Ph.D., of the University of Texas MD Anderson Center, Houston, examined patterns of primary tumor resection (surgery) and survival in stage IV colorectal cancer in the United States. Their study appears today in the journal JAMA Surgery. 

  0 comments

Wednesday, June 4, 2014


Colorectal cancer screening saves lives

Courtesy American Cancer Society YouTube
CANCER DIGEST – June 4, 2014 – Screening for colorectal cancer is working, according to a massive analysis of data from National Cancer Institute’s Surveillance, Epidemiology and End Results (SEER) database. SEER logs information from all cancer cases in the U.S. The analysis looked at screening for colorectal cancer over three decades from 1986 to 2010 and cancer colorectal cancer incidence between 1976 and 2009. They found that from 1987 to 2010 the percentage of adults 50 and older who underwent colorectal cancer screening increased from 34.8 percent to 66.1 percent. During that time the incidence of late-stage colorectal cancer declined from 118 cases per 100,000 people to 74 cases per 100,000 people. The incidence of early-stage colorectal cancer also decreased from 77 cases per 100,000 to 67 cases per 100,000. After adjusting for trends in cancer incidence, the researchers calculated that colorectal cancer screening could be linked to a 550,000 reduction in the number of cases. They published their results online in the June 3, 2014 journal Cancer.

Monday, March 31, 2014



Aspirin after colon cancer therapy linked to immune system

JAMA INTERNAL MEDICINE – Mar. 31, 2014 –Patients who took aspirin after surgery for colon cancer had a better chance of surviving if the tumor expressed a particular immune system antibody generator. Researchers at Leiden University Medical Center, the Netherlands, examined tumor tissue to try to determine the mechanism by which aspirin might increase survival.  Of the 999 patients, 182 (18.2 percent) were aspirin users and among them there were 69 deaths (37.9 percent). There were 396 deaths among 817 nonusers of aspirin (48.5 percent). The survival benefit of aspirin use was greatest for those whose tumors expressed a protein called HLA-1, which is part of the signaling the immune system uses to determine which cells to attack.



FDA panel not impressed with one colon cancer test, more favorable to another

CBS-DC NEWS – Mar. 24, 2014 – An FDA advisory panel was not impressed with the Epi proColon genetic test that has been approved in Europe and Argentina. In the manufacturer's key study involving more than 1,500 participants (including 44 with cancer confirmed by colonoscopy), the test detected 68 percent of the cancers, but only correctly ruled out cancer 79 percent of the time, in other words it had a high false-positive rate. The panel noted that this specificity value completely failed to meet the prespecified target of 85 percent. The panel also favorably reviewed a similar test, called Cologuard, by Exact Sciences, that uses a DNA marker to detect cancer. In a study of 10,000 people, the test correctly detected 92.3 percent of cancers, and correctly ruled out cancer 84 percent of the time. The panel is expected to recommend the Cologuard test for approval with conditions for additional research following marketing of the test.


Monday, March 17, 2014

Big drop in colon cancer rate



MEDICAL NEWS TODAY – Mar. 17, 2014 – Colon and rectal cancers have dropped dramatically as older Americans get colonoscopies a new report from the American Cancer Society has found. While colonoscopies have nearly tripled among those 50 and older, and the colon cancer rate has dropped by 30 percent over the last 10 years.  The report appears in the organization’s Colorectal Cancer Statistics 2014, which is due out in the March/April issue of the journal CA: A Cancer Journal for Clinicians.

May 10, 2010 – ATLANTA (Cancer Digest) –  Cost of cancer care doubled? So have other healthcare costs\
April 27, 2010 – DURHAM, N.C. – (Cancer Digest) – Use and costs of imaging rising faster than cost of cancer care
April 19, 2010 – CHICAGO (Cancer Digest) – Volume isn't only factor to consider for colon surgery