In a study led by Tobias Nordstrom and published online Aug. 12, 2021 in Lancet Oncology, 12,750 men from Stockholm were given the PSA (prostate specific antigen) blood test that was analyzed using the Stockholm3 algorithm, which looks for a specific combination of protein markers, genetic markers and clinical data.
With results from that blood test showing elevated PSA the men were randomly selected for traditional biopsies or MRI (magnetic resonance imaging). In the MRI group biopsies were only conducted on suspected tumors shown on the MRI.
The study showed that the combination of the blood test with MRI reduced over diagnosis of low-risk tumors by as much as 69 percent, and cut the number of needless biopsies in half. The result makes the combination of the blood test with Stockholm3 analysis and MRI more cost effective.
“Overall, our studies show that we have identified the tools needed to be able to carry out effective and safe screening for prostate cancer," Nordstrom said in a press release. "After many years of debate and research, it feels fantastic to be able to present knowledge that can improve healthcare for men.”
“Overall, our studies show that we have identified the tools needed to be able to carry out effective and safe screening for prostate cancer," Nordstrom said in a press release. "After many years of debate and research, it feels fantastic to be able to present knowledge that can improve healthcare for men.”
Source: Karolinska Institute press release
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