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| Image courtesy CHOP News |
Researchers at Children’s Hospital of Philadelphia (CHOP) and the Perelman School of Medicine analyzed the largest group of pediatric patients to date with high-risk neuroblastoma treated with proton therapy.
Neuroblastoma is a cancer of immature nerve cells found most commonly in the adrenal glands. The study is published online in the International Journal of Radiation Oncology.
"We've shown PRT is not only effective in the treatment of high-risk neuroblastoma, but it also spared damage to the developing liver, kidneys and bowel that may occur in pediatric patients exposed to traditional radiation," said lead author Christine Hill-Kayser, MD, Chief of the Pediatric Radiation Oncology Service at Penn Medicine and an attending physician in a press release.
Researchers studied 45 patients with high-risk neuroblastoma who received PRT at both institutions between 2010 and 2015. After five years, researchers found that 82 percent of patients survived, and 97 percent were free of a primary site tumor recurrence. The current 5-year survival for high-risk neuroblastoma is between 40 percent and 50 percent, according to the Cancer.net of the American Society of Clinical Oncologists (ASCO).
Side effects were minimal with no patient experiencing severe side effects to their kidneys or livers. The majority of patients experienced mild side effects.
Unlike traditional radiation therapy using x-rays, proton therapy is a non-invasive, precise cancer treatment that uses a beam of protons moving at very high speeds to destroy the DNA of cancer cells, killing them and preventing them from multiplying. Doctors are able to control the depth of the very precise beam, which allows them to minimize radiation damage to nearby organs.
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